Without taking a break and wearing four-inch heels throughout her speech, the 77-year-old Democrat quoted from the Bible and Pope Francis during her record-long address in the House of Representatives.
"If a Dream Act were brought to the floor, it would pass immediately, with strong bipartisan support", Pelosi said Wednesday in a speech on the House floor.
Pelosi utilized the magic-minute rule of the House, which permits the majority leader, the minority leader and the House speaker to speak as long as they wish.
"I'm a no", the New Mexico Democrat said, noting that her caucus took that position as well.
Pelosi also repeatedly framed the immigration debate in moral terms, at times reading directly from the Gospel of Matthew.
Senate lawmakers are preparing for an open floor debate on immigration sometime next week, which McConnell has promised will result in some kind of final DACA package.
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Donald Trump, the president, has called on Congress to provide a path to citizenship for Dreamers as part of an immigration and border security proposal.
The legislation could face barriers in the House without a commitment from the speaker, Paul Ryan, to consider legislation that would protect Dreamers. The House did approve a temporary spending bill to extend most agency funding until March 23 and promptly sent it to the Senate for consideration. Pelosi shared stories of people who are in the country illegally in the hopes of convincing Speaker Paul Ryan to include protections for DACA recipients in the deal.
She used her unlimited, "magic" minute, available in the House only to party leaders, to speak for eight hours, reading story after emotional story about DREAMers who aspire to become US citizens. Her parents, she said, did not report the crime because they were afraid of being deported.
By telegraphing their hesitance to force another shutdown, and then agreeing to a long-term budget deal, Democrats gave up the one source of leverage that the minority party held to force a DACA fix.
A harried staffer rushed up to hand her a final Dreamer's story as she tried to close her speech, prompting a Democrat to yell from a few rows back, "Read them all!"
On Wednesday Pelosi seemed to confirm just that at an unrelated infrastructure press conference when asked whether she was whipping against the spending deal.
"Fox & Friends" co-host Steve Doocy noted that Pelosi "was essentially filibustering something that she was in on negotiating".