Multiple medical helicopters responded to the crash scene on I-10, about 20 miles east of Mobile and the injured were transported to several local hospitals in the area.
"There's at least one confirmed fatality at this point", Lowery said by telephone.
Baldwin County Sheriff Huey Hoss Mack said there were about 45 people were on board, and that the victims were brought to 10 hospitals in Alabama and Florida.
Baldwin County commissioner Christ Elliott said first responders "are having to rappel down" to access the crash site. WALA reports five of the passengers are in serious condition and one in critical condition.
"All that she remembers is that she felt a bump, then a crash and then the bus flipping onto its side", Torres said.
Channelview High School Falcon Band at Disney World.
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Rescuers used every piece of equipment on every truck to reach them, Mack said: "This is what we call an all-out".
Baldwin County officials say emergency personnel located and evacuated the passengers of the bus.
One image showing happy band members at Disney World was posted only hours before the crash.
A charter bus transporting Channelview High School band students was involved in an accident on Interstate 10 in Alabama early this morning.
The bus had been due to take the children back home to Channelview, Texas, in Houston. A deputy suffered minor injuries while pulling people from the bus.
The Alabama Law Enforcement Agency is investigating and more information will be provided as it becomes available.
Texas Gov. Greg Abbott offered his condolences to those affected by the crash, saying in a statement: "I pray for a speedy recovery for all those injured, and I am especially grateful for the heroic actions of the Alabama first responders that undoubtedly helped save lives today".