At the Theatre, Mrs Trump shall be joined by Kenya's First Lady Margaret Kenyatta and US Ambassador to Kenya Robert Godec.
She will also visit Malawi, Kenya and Egypt to complete her week-long visit to Africa.
She took to twitter to say "Thank you #Ghana!"
During Trump's tour, she is focusing on child welfare.
At the primary school, the first lady watched dozens of pupils sitting on the ground in the sun as a teacher taught on a blackboard on the side of a building.
Trump is advocating for children's welfare as part of her "Be Best" campaign during her first worldwide solo tour as first lady. "We are happy today, we are happy today to see you". More girls than boys were in the first outside lesson, which totaled 275 students.
"I am very proud to see the first lady", high school student Sharon Sibo told AFP after being among a group of welcoming pupils at the airport.
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Trump also had tea with Ghana's first lady, Rebecca Akufo-Addo, at the presidential palace. "Takulandirani [Welcome] First Lady Melania Trump" was spelled out in red, white, and blue letters on the chalkboard.
School educators also explained to the first lady how important the USAID textbook donations, which help power the country's National Reading Program, are to children at the school.
The convoy of the US First Lady however passed by without any incident and Mrs Trump might have seen the protests.
"I was heartened to spend time with the students and was honoured to donate school supplies and soccer balls", she said.
First Lady Melania Trump (L) and the first lady of Malawi Gertrude Maseko walk at the State House in Lilongwe, on October 4.
After the talks, Melania is scheduled to watch a performance by Sarakasi dancers at the Kenya National Theater.