Lionel Messi out of El Clasico as he fractures arm against Sevilla

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At first Barca seemed unconcerned by Messi's injury, with Ousmane Dembele taking an age to warm up.

It was a ridiculous 15 minutes for Lionel MESSI against Sevilla as he scored, assisted and got injured.

'He will be out for approximately three weeks'.

It remains to be seen how Barca's Champions League group looks ahead of their trip to San Siro, but there can be little doubt that this will be their trickiest away match before the knockout phase.

"In the end, it is about who he is and we know what he gives us".

Messi has missed 61 matches since the start of the 2010-11 season through injury, suspension and rest - Barca losing only six, with four in La Liga, and by contrast winning 49.

Ernesto Valverde didn't count on Arturo Vidal before his social media outbursts in light of his lack of game time at Barcelona and he doesn't now either.

Messi set up Philippe Coutinho for Barca's opener in the second minute at Camp Nou before doubling the lead himself with a fine strike from 20 yards.

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At the least, Messi will miss playing Inter Milan in the Champions League on Wednesday, and the clasico against Real Madrid next weekend.

However, Inter believe it is a great shame that Messi might not feature against them and replied to Barcelona with a wonderful tweet.

Real, meanwhile, have problems of their own heading into the clash, having slipped to a fourth defeat in five games through a shock home loss to Levante on Saturday. Suarez buried the penalty.

Sevilla did indeed have one back in the 79th minute when Sarabia's deflected effort found a route past Ter Stegen.

The club's previous worst run had been 464 minutes, in 1985.

Real are fifth in the La Liga standings, three points behind leaders Alaves.

Asked about rumours that Lopetegui could be sacked, Sergio Ramos replied: 'I always said that manager changes are never good for anyone.

"With this initiative, we continue to fight against the cruel disease that is cancer.Collaborating makes this easier".

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