Residents of the resource-rich province, which borders Iran and Afghanistan, have long complained that it does not receive a fair share of the profits made from its mineral wealth.
Karachi's police chief said three attackers arrived at the consulate in a auto filled with explosives but were killed in a shootout before they could enter.
-AFP A BDS official checks a bag belonging to an attacker outside the Chinese consulate.
Chinese Foreign Ministry spokesperson Geng Shuang condemned the attack and offered condolences to the victims.
He told reporters in the capital, Islamabad, that the attack was a "conspiracy" against Pakistan and China and blamed an "enemy of Pakistan".
Neighbour China is Pakistan's closest ally and its main benefactor, ploughing in billions of dollars in infrastructure projects, as part of its vast Belt and Road initiative.
Pakistani Prime Minister Imran Khan called it "part ofconspiracy" against Pakistani and Chinese economic and strategic cooperation and ordered an inquiry, his office said.
Officials told the BBC's Stephen McDonell in Beijing they were confident the Pakistani government was able to manage the security situation to guarantee Chinese investment.
"They tried to get inside, but the Rangers and police killed one of the terrorists", Shaikh said.
The Balochistan Liberation Army claimed responsibility for that attack.
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Security personnel cordoned off the area after the blast and launched a search operation.
Investigators probing a foiled attack on the Chinese consulate in Karachi disclosed that the assault was orchestrated by a commander of the outlawed Balochistan Liberation Army (BLA) militant group.
Investigators look at the belongings of attackers including grenades outside the Chinese consulate after an attack in Karachi.
He termed the incident an attack on the Pakistan-China friendship and economic cooperation, adding that such forces can not spoil the bilateral ties.
"(The consulate is in) a very heavily guarded area, the firing is still continuing and we can hear small blasts, which suggests the attackers are still engaged with security forces", Latif said.
"Chinese workers have come under attack in recent years in some remote regions but today is the first high profile attack on a Chinese facility in a Pakistani city".
"There were three attackers and all three have been killed".
Orakzai has been the scene of militant attacks in recent years, mostly claimed by Pakistani Sunni militants.
As a native of the southern province of Sindh, Talpur has spent her whole life fighting to make her mark in a conservative region where the idea of even educating girls is frowned upon.
Hundreds of Chinese nationals are presently working in Pakistan specially in Karachi and the restive Balochistan province on projects of the CPEC and on other business ventures.