For the prince, it's about the killing of a dissident Saudi journalist in the country's Istanbul consulate.
Amidst heightened global scrutiny of the young Saudi leader following his alleged role in the murder of Washington Post columnist Jamal Khashoggi, MBS was all smiles when he greeted the Russian strongman in Argentina on Friday.
In contrast, Mr Putin and the crown prince shared a smiley, enthusiastic greeting at the gathering.
Saudi Arabian Crown Prince Mohammed bin Salman arrived in Buenos Aires, Argentina, on 28 November to attend the annual G20 summit.
Saudi Crown Prince Mohammed bin Salman and Russian President Vladimir Putin were caught high fiving at the G20 summit in Argentina.
However, some of the most interesting interactions are happening on the summit's sidelines, amid stand-offs over the US-China trade row, Russia's conflict with Ukraine and Saudi Arabia's involvement in the murder of journalist Jamal Khashoggi.
"We might [later], but we had none", President Trump told the press pool.
Earlier on Friday, Prince Mohammed met Indian Prime Minister Narendra Modi and told him about plans to scale up investments in India's tech, farm and energy sectors, an Indian official and the Saudi news agency (SPA) said on Friday.
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Six hostages - including a rabbi and his pregnant wife - were killed at Nariman House, a Jewish cultural and religious centre. Nine of the attackers were killed by police, while lone survivor Ajmal Kasab was captured and hanged after a trial in India.
At the end Mr Macron can be heard saying: "I am a man of my word".
Macri has said accusations that Prince Mohammed was involved in Khashoggi's death could be discussed by world leaders during the two-day summit.
The Elysee Palace also said Macron stressed the need to find a political solution to the war in Yemen in his conversation with bin Salman, whose country's brutal military campaign has left thousands of Yemenis dead over the past four years and pushed the impoverished nation to the brink of starvation.
After repeated denials of any knowledge about Khashoggi's disappearance, Saudi Arabia finally admitted the 59-year-old had been murdered at the mission in a "rogue" operation.
Mattis and Pompeo urged senators to support the United States involvement in the war in Yemen, including assistance to Saudi Arabia.
French President Emmanuel Macron also spoke to the prince about the killing Khashoggi, his office confirmed.
During the course of the day, President Trump "exchanged pleasantries" with Salman, telling reporters that while they didn't talk about hot-button issues concerning the USA and Saudi Arabia, it was possible the pair would do so as the summit rolled on.
A senior White House official said the two exchanged pleasantries.