His replacement Santiago Solari, Real Madrid's youth team coach has been handed a two-and-a-half-year deal, but there are no guarantees he will remain beyond the end of the season because the reigning European champions have been below par in the Spanish league this season.
Solari also addressed Isco's Instagram post in which the attacking midfielder asked fans if he looked overweight, and took the opportunity to speak on the importance of team selection.
"There's no time to think about it".
The fixture was a curtain raiser for Sunday's Copa Libertadores second leg final between Argentinian rivals Boca Juniors and River Plate. We're happy to have him back playing and looking comfortable. There are many matches before that.
The German has had an issue with his knee since taking on Roma in Italy and this is a cause for concern for Solari, but the coach is being patient and allowing the player to fully recover ahead of the Club World Cup.
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Isco and Vinicius Junior added two more before Melilla, a tiny Spanish autonomous enclave in north Africa, scored through striker Yacine Qasmi's 81st-minute penalty.
Solari said: "Today's game was beneficial".
Real Madrid players celebrate after entering the last-16.
"Vinicius plays on the left and we adjust the positions accordingly. They're top of their group in Segunda B. Scoring 10 goals in two games isn't easy and I'm thrilled for everyone who was involved today".
Nacho is out for Real Madrid, though they should be able to start a full-strength backline.